UNI Technology

VACCINE DELIVERY COMPARISON

Below is a brief comparison that can be made between the UNI Technology and conventional injections for the delivery of vaccines (immunizations). There is also included some comparison to the approved nasal vaccine delivery technology FluMist, which is nothing more than the conventional injection 'syringe' utilizing a 'spray tip' instead of a needle, etc.. Conventional injections are used to deliver over 90% of worldwide immunizations.

Nasal Insert Technology Injections
(+) Painless (-) Quite Painful
(+) Low patient 'fear' level = increased patient compliance (-) High patient 'fear' level = decreased patient compliance
(-) Nasal Sprays (FluMist) - medium patient 'fear' level = decreased patient compliance
(+) No need to combine vaccines (i.e., MMR) (-) Increased need to combine - fewer painful 'shots'
(+) Does not create bio-hazard waste (-) Creates the most dangerous & expensive
(+) Has access to ‘over’ 90% of the body’s immune system cells (-) Has access to ‘less than’ 10% of the body’s immune system cells
(+) Smaller dose size required (-) Larger dose size required
(+) Less pure vaccine per/dose required (-) More pure vaccine per/dose required
(+) Would extend limited vaccine supplies (-) Consumes limited vaccine supplies
(+) Decreased need to add 'toxic' vaccine (-) NA(Not Applicable) - Poor immune system access requires the excipients (i.e., adjuvants, preservatives, GMO’s) addition of 'toxic' vaccine excipients
(+) Vaccine could be safely 'self-administered' by the patient = increased patient compliance (-) NA - Vaccine injections must be administered by trained healthcare staff
(-) NA - Vaccine nasal sprays (FluMist) must be administered by trained healthcare staff
(+) Vaccine dose can be delivered over many hours of time (-) NA - Dose is delivered in under 5 seconds
(-) NA - Nasal spray dose (FluMist) is delivered in under 5 seconds
(+) Massively extends nasal residence time of vaccine in nasal mucosa by 'hours' (-) NA - Injections have no access to nasal mucosa
(-) Nasal sprays (FluMist) are rapidly cleared from nasal mucosa within 20 min.
(+) Increased nasal residence time greatly increases vaccine bio-absorption (-) Injections offer low vaccine bio-absorption
(-) Nasal vaccine sprays offer low vaccine bio-absorption
(+) Increased vaccine bio-absorption reduces vaccine waste (-) Poor vaccine bio-absorption increases vaccine waste
(+) Increased vaccine bio-absorption reduces potential side effects (-) Poor vaccine bio-absorption increases potential side effects
(+) Increased vaccine bio-absorption reduces environmental impact on drinking water supplies (-) Poor vaccine bio-absorption increases environmental impact on drinking water supplies
(+) Low tendency to ‘shock’ and ‘overload’ the immune system (-) Injections and nasal vaccine sprays are 'designed' to shock and overload the immune system
(+) Vaccine flow into the body can be 'halted' or controlled if there are indications of an allergic or adverse reaction (-) NA - Vaccine flow into the body 'cannot' be halted or controlled
(-) NA - Nasal sprays into the body 'cannot' be halted or controlled
(+) UNI per/unit manufacturing costs – Very low (-) Needled Syringe per/unit manufacturing cost – Very high*
(-) Nasal spray devices per/unit manufacturing cost - High

(* + Plus the cost of medical sharps bio-hazard waste disposal + Plus the costs of medical sharps related injuries.)
(+) Far less fragile. Simple to handle and transport (-) Injections - Fragile. Dangerous to handle and transport
(-) Nasal sprays - Difficult to handle and transport
(+) Very low chance for human error (-) Injections - High chance for human error
(-) Nasal sprays - Medium chance for human error
(+) Extremely low risk of accidents during administration to patients (-) Injections - Very high risk of accidents to patients during administration
(-) Nasal Sprays - Medium risk of accidents to patients during administration
(+) Extremely low risk of accidents to healthcare staff (-) Injections - Very high risk of accidents to healthcare staff
(-) Nasal sprays - Medium risk to healthcare staff